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I enquired on this before from nestle. Not much of a difrerence, just that HA is suitable for those baby with sensitive tummies or with allergies. Thank you for contacting Nestle Baby Club. NAN OPTIPRO (RENAMED SUPREMEPRO) series - our advance formulation with highest 2’-FL and Immunity Guardians, contains OPTIPRO proteins --- i.e. Optimized Protein – proteins that are optimized in the right concentration and composition for optimized growth and immunity. NAN SUPREMEPRO H.A series - our breakthrough formulation to support immunity and beyond. It is a hypoallergenic, containing Gentle OPTIPRO®️ H.A., a unique blend of whey proteins which are partially hydrolyzed to help reduce the allergenic potential of cow's milk, together with the highest combination of DHA and ARA.

Thanks

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