It has all to do with genetics and RH factor. It can happen. I know because I am having a negative blood group (O+) while my daughter has the blood group (A-). http://kidshealth.org/en/parents/rh.html http://www.rhnegativeregistry.com/Rh_Negative_Mother_Pregnancy_RhoGAM_Anti_D_HDN.html
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