My wife is highly against the idea of getting our daughter (and soon to be son) vaccinated! I completely disagree with her and think vaccinations are the right approach. How can I explain to my wife my point of view? What are your thoughts on the matter?

Ask her first regarding her hesitations on getting vaccines for your children, so you will also understand where she is coming from. Then you can explain your side, including the data/facts/resources why you want to have your kids vaccinated. Most of my friends only give the DOH required vaccines. Personally, I follow our pediatrician's advise.