What is the best words to say to a relative who’s been trying to conceive since 14years back? :( The beloved couple is almost in their early 40's already.

I'm afraid time is not on their side and chances are slim. It is still possible for them to conceive though. If you are afraid that feelings will get hurt, sometimes it is best to not say anything. You could get them to try out this potion of dates and honey. Apparently it helps to boost fertility, though results may vary. http://mummiesvoices.com/2015/12/08/sharing-the-baby-making-magic-potion/