What is the best words to say to a relative who’s been trying to conceive since 14years back? :( The beloved couple is almost in their early 40's already.

I have been trying to conceive since 10 and a half years back. I'm now in my late 30s. I've tried means and ways to get pregnant. Western ways: 7 IUIs, 3 IVFs, 1 embryo transfer. Eastern way: Traditional Chinese Medicine for many years and Acupuncture. Still no pregnancy at all. Imagine the hardship someone like me has to go through and yet I see my AF (aunt flow) appear every month. It's not easy. In the first few years of marriage, people ask why I am not trying. After a few years of marriage, people ask why I don't want or suggest that I see a doctor. These few years, they stopped asking about it at all. I appreciated that. I guess best is not to say anything at all, unless they broach the topic to you.