Yes nag open cervix q nung 28weeks aq due to uti and yeast infection.. Nag spotting aq and oinag antibiotics and duphaston aq nag hoard aq ng duphaston... 2 weeks prescription sa akin.. But every time na tumigas at mag hilab ng more than 2 hours ang tyan q umiinom aq ulit ... 34 weeks na aq bukas.. Effective ang duphaston for me.