Recently my LO has been nursing most of the time as she is sick. I tried to pump when my baby is sound asleep or back in infant care. I am unable to pump milk efficiently. I used to pump 200 - 250ml every 6hrly. Now I pump, only less than 100ml. I have to use hand express so that my breast will not be engored. I wonder is it my pump or Mayb my breast is not responding to the pump. Mayb my bf journey is coming to an end?

If your baby was able to nurse substantially when she was ill, then I reckon it's not a supply problem -- I think maybe your breasts became more receptive to baby's suckling and are not as responsive to pumping as before. More nursing/pumping results in a greater milk supply. If you consistently reduce the amount of time nursing or pumping for several days, your overall milk supply will decrease and you can expect to see a decrease during pumping. Keep pumping and nursing the next couple of days and see if the output increases.