Firstly, I must tell you that you guys are really brave enough to decide that you will manage the both kids on your own when you have also to work simultaneously.
Anyway, I think you guys should set up a schedule for the kids and work during the hours when they are sleeping. Or engage them in some activity where they both help each other doing things.
http://www.thesimpledollar.com/17-strategies-to-survive-working-from-home-with-children/
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