Taking the Rhogam shot due to rhesus incompatibility is generally not a painful experience. The shot is usually given in the arm or hip, and the patient may feel a slight pinch or sting. The shot is typically administered in one visit and the patient may experience some soreness or redness at the injection site. The Rhogam shot is a safe and effective way to prevent Rh incompatibility between mother and baby. The shot is usually given during the 28th week of pregnancy, and again 72 hours after delivery if the baby is Rh-positive. Some people may also experience a mild fever, headache, or nausea as a side effect.