What is the best words to say to a relative who’s been trying to conceive since 14years back? :( The beloved couple is almost in their early 40's already.

The best is not to say anything unless they themselves touch on the topic or ask for your opinion. If it is me I won't like it when people busybody and act as if they know everything by telling me don't worry keep trying or maybe you should go see this doc that doc. We are not in their situation and don't know what they have gone thru or going thru so we should not give our two cents worth just because we feel we should. Silence is golden sometimes